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What precisely is mescaline, where does it originate, and what effects does it have on a person who takes it?

Mescaline, or 3,4,5-trimethoxyphenethylamine as chemists refer to it, is an alkaloid that is typically found in peyotes but can also be found in other cacti such as Peruvian torch and San Pedro. For research purposes, mescaline that has been synthesized in a lab is also accessible.

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If your tour guide ever told you not to eat any random local cacti in case you were in a survival situation while you were out in the desert, this is the reason why: It’s not good to end up tripping over obstacles or poisoning yourself while dehydrated in the scorching sun—you need your brains to survive.

Well, what will mescaline do to you if you aren’t stuck in the middle of Death Valley, anyway? What are the advantages of the psychedelic plant, and what are the possible risks?

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DOSAGE AND CONSUMPTION

Native Americans have been consuming peyote for thousands of years as part of spiritual ceremonies. The buttons of the cactus, which grow on top of the roots, are harvested in order to cultivate mescaline. The buttons can be brewed into a tea or powdered to create mescaline capsules once they have dried.

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Ten to twenty grams of dried peyote buttons, with a mescaline content of no more than 100 mg, is the standard starting dose. Mescaline takes about one to three hours to start working after ingestion, and its effects continue for about ten to twelve more hours. Of course, the length and intensity of a trip depend on the dose.